Application of p16/Ki-67 dual-staining cytology in cervical cancers
نویسندگان
چکیده
منابع مشابه
Evaluation of p16/Ki-67 dual staining in detection of cervical precancer and cancers: a multicenter study in China
PURPOSE To analyze the clinical performance of p16/Ki-67 dual-stained cytology identifying high-grade cervical intraepithelial neoplasia (CIN2+) in Chinese women. METHODS 1079 women attending ongoing cervical cancer screening and 211 "enriched" women aged ≥30yrs with biopsy-confirmed CIN2+ from five Chinese hospitals were enrolled during year 2014-2015. Cervical specimens were collected for h...
متن کاملScreening for Cervical Cancer Precursors With p16/Ki-67 Dual-Stained Cytology: Results of the PALMS Study
BACKGROUND Pap cytology is known to be more specific but less sensitive than testing for human papillomavirus (HPV) for the detection of high-grade cervical intraepithelial neoplasia (CIN2+). We assessed whether p16/Ki-67 dual-stained cytology, a biomarker combination indicative of transforming HPV infections, can provide high sensitivity for CIN2+ in screening while maintaining high specificit...
متن کاملCervical Cytology in Postmenopausal Women of Lucknow Rural Areas, India
Introduction: As carcinoma cervix mostly occurs after the age of 50 in women, it is mandatory to cytologically examine all the postmenopausal women above 45 to detect the onset of any premalignant changes in the cervix. The present study was conducted on 537 postmenopausal women living in rural areas and the collected data were analyzed in terms of predisposing factors of cervical carcinogenesi...
متن کاملCervical Cytology in Postmenopausal Women of Lucknow Rural Areas, India
Introduction: As carcinoma cervix mostly occurs after the age of 50 in women, it is mandatory to cytologically examine all the postmenopausal women above 45 to detect the onset of any premalignant changes in the cervix. The present study was conducted on 537 postmenopausal women living in rural areas and the collected data were analyzed in terms of predisposing factors of cervical carcinogenesi...
متن کاملComparison of the sensitivity and specificity of p16/Ki-67 dual staining and HPV DNA testing of abnormal cervical cytology in the detection of histology proven cervical intraepithelial neoplasia grade 2 and above (CIN 2+).
INTRODUCTION Human papillomavirus (HPV) testing is used as a means of triaging cervico-vaginal smears with low grade squamous abnormalities or as part of co-testing with cytology. While HPV testing has a high sensitivity, it has a low specificity in detecting cervical intraepithelial neoplasia grade 2 and above (CIN 2+) leading to unnecessary colposcopy referrals. We investigate the accuracy of...
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ژورنال
عنوان ژورنال: Journal of Cancer
سال: 2019
ISSN: 1837-9664
DOI: 10.7150/jca.32743